Novoleukin-C Blood Test

Novoleukin-C Test measures gluten-specific CD4+ T cells

Celiac Disease is caused by an abnormal Intestinal T cell response to gluten proteins of wheat, barley and rye.


Unlike current clinical diagnostic tests that measure the effects of gluten in celiac disease, the Novoleukin-C blood test aims to measure the specific T cells that cause celiac disease. The Novoleukin-C blood test promises to be the first test capable of diagnosing celiac disease with high sensitivity and specificity, without requiring intestinal biopsies - even in individuals who have avoided dietary gluten. The Novoleukin-C test is also a flexible platform that can be customised to monitor specific populations of gluten-reactive T cells targeted by novel therapies or present only in certain genetic forms of celiac disease.


The approach developed for celiac disease now provides a broad platform that can be customised for detection and characterising rare antigen-specific T cells in other conditions.

The Novoleukin-C Test is based on

Fundamental research by Novoviah Pharmaceuticals’ scientific founder, Dr Robert Anderson, who has pioneered blood tests for celiac disease utilizing gluten-specific CD4+ T cell measurement without the requirement for intestinal biopsies or complex laboratory methodologies.


The Novoleukin-C test builds on detailed understanding of the gluten peptides recognized by CD4+ T cells in celiac disease, and a series of advances that have improved test sensitivity. The Novoleukin-C test utilizes fresh whole blood incubated with gluten antigen to assess interleukin-2 released by activated T cells. The prototype laboratory test detects as few as 1 cell per mL of blood responding to gluten antigen in patients with celiac disease.



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